反应详情

Ethyl 4-fluoro-3-nitrobenzoate 9.16 g, 2-(1-ethylpropyl)-1H-imidazole 5.94 g, N,N-diisopropylethylamine 11.2 mL and acetonitrile 86 mL were mixed and heated under reflux for 15 hours in nitrogen atmosphere. From the reaction liquid the solvent was distilled off, and the residue was dissolved in ethyl acetate and rendered weakly alkaline with saturated aqueous sodium hydrogencarbonate solution. The organic layer was separated, washed with water and dried over magnesium sulfate. Distilling the solvent off, 13.16 g of the title compound was obtained.

1. temperatureheated
2. temperatureunder reflux for 15 hours in nitrogen atmosphere
3. customFrom the reaction liquid the solvent
4. distillationwas distilled off
5. dissolutionthe residue was dissolved in ethyl acetate
6. customThe organic layer was separated
7. washwashed with water
8. dry with materialdried over magnesium sulfate
9. distillationDistilling the solvent off, 13.16 g of the title compound
10. customwas obtained