Hydrochloric Acid → 1-{2-Amino-6-[(2-aminoethyl)amino]pyridin-3-yl}-2,2,2-trifluoroethanone hydrochloride

HRID 57687Notes

Reaction equation

HRID 57687 reaction equation
C(OC([NH:8][CH2:9][CH2:10][NH:11][C:12]1[N:17]=[C:16]([NH:18]C(=O)OC(C)(C)C)[C:15]([C:26](=[O:31])[C:27]([F:30])([F:29])[F:28])=[CH:14][CH:13]=1)=O)(C)(C)C.[ClH:32]>O1CCOCC1>[ClH:32].[NH2:18][C:16]1[C:15]([C:26](=[O:31])[C:27]([F:28])([F:30])[F:29])=[CH:14][CH:13]=[C:12]([NH:11][CH2:10][CH2:9][NH2:8])[N:17]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57911745tert-Butyl [6-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-3-(trifluoroacetyl)pyridin-2-yl]carbamate

Product 1

HCID 670603221-{2-Amino-6-[(2-aminoethyl)amino]pyridin-3-yl}-2,2,2-trifluoroethanone hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2.5 g (5.57 mmol) of tert-butyl [6-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-3-(trifluoroacetyl)-pyridin-2-yl]carbamate (Example 33A) were dissolved in 15 ml of a 4N solution of hydrogen chloride in dioxane, and the mixture was stirred for 20 h. The reaction mixture was concentrated to half of its original volume and the same amount of diethyl ether was added. The reaction mixture was stirred for 20 min and the product was filtered off and washed with diethyl ether. This gave 1.4 g (89% of theory) of the product as a solid.

Workup

  1. concentrationThe reaction mixture was concentrated to half of its original volume
  2. additionthe same amount of diethyl ether was added
  3. stirringThe reaction mixture was stirred for 20 min
  4. filtrationthe product was filtered off
  5. washwashed with diethyl ether

Sources & evidence

ORD record
ord-16c350395ede450991a3bdc01ac2fbdf
Source dataset
uspto-grants-2016_09
Patent number
US09434731B2

Reaction notes

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