反应详情

温度

140 °C

1.0 g (4.99 mmol) of tert-butyl 3-aminopiperidine-1-carboxylate and 1.383 g (9.99 mmol) of 6-chloropyridine-3-carbonitrile and 1.29 g (9.99 mmol) of diisopropylethylamine were suspended in 40 ml of DMSO and heated in a microwave at 140° C. for 45 min. Most of the DMSO was removed from the mixture by kugelrohr distillation, water was added and the resulting precipitate was filtered off. Drying under high vacuum gave 2.24 g (46% of theory) of the product.

1. customMost of the DMSO was removed from the mixture by kugelrohr distillation, water
2. additionwas added
3. filtrationthe resulting precipitate was filtered off
4. customDrying under high vacuum
5. customgave 2.24 g (46% of theory) of the product