2-(Bromomethyl)-1,3,4-trichlorobenzene → HCID 178516528, compound

HRID 576915Notes

Reaction equation

HRID 576915 reaction equation
Br[CH2:2][C:3]1[C:8]([Cl:9])=[C:7]([Cl:10])[CH:6]=[CH:5][C:4]=1[Cl:11].[SH:12][C:13]1[N:18]=[C:17]([OH:19])[CH:16]=[CH:15][N:14]=1>>[Cl:9][C:8]1[C:7]([Cl:10])=[CH:6][CH:5]=[C:4]([Cl:11])[C:3]=1[CH2:2][S:12][C:13]1[N:18]=[C:17]([OH:19])[CH:16]=[CH:15][N:14]=1

Participants

3

Reactant 2

HCID 786622-(Bromomethyl)-1,3,4-trichlorobenzeneHCID 1785165292-sulfanylpyrimidin-4-ol

Product 1

HCID 178516528HCID 178516528, compoundYield 89%

Procedure

As per procedure from Example 1, this compound was prepared from 2-(bromomethyl)-1,3,4-trichlorobenzene and 2-sulfanylpyrimidin-4-ol to provide the title compound as a white solid (1.04 g, 89% yield); 1H NMR (400 MHz, DMSO-do): δ 4.72 (s, 2H), 6.21 (bs, 1H), 7.58 (d, J=8.8 Hz 1H), 7.68 (d, J=8.8 Hz 1H), 8.02 (bs, 1H); M+ 322.8.

Sources & evidence

ORD record
ord-0a80ab69f682463ebbbdca7727bd99f0
Source dataset
uspto-grants-2015_05
Patent number
US09040538B2

Reaction notes

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