反应详情

To a mixture of 2-{[(2-chloro-5-nitrophenyl)methyl]sulfanyl}-6-methylpyrimidin-4-ol (500 mg, 1.6 mmol) in absolute EtOH (15 mL) was added hydrazine hydrate (1 mL, 32 mmol) and Raney nickel. The reaction mixture was stirred at room temperature overnight. The solid material was filtered on Celite. The pad was recovered and suspended in a mixture of MeOH/EtOAc/CH2Cl2 (100 mL). The mixture was filtered. The filtrate was recovered, evaporated, and dried in vacuo, affording the 2-{[(5-amino-2-chlorophenyl)methyl]sulfanyl}-6-methylpyrimidin-4-ol (45 mg, 10% yield). The product was used without further purification.

1. filtrationThe solid material was filtered on Celite
2. customThe pad was recovered
3. additionsuspended in a mixture of MeOH/EtOAc/CH2Cl2 (100 mL)
4. filtrationThe mixture was filtered
5. customThe filtrate was recovered
6. customevaporated
7. customdried in vacuo