反应详情

6-methyl-2-[(pyridin-4-ylmethyl)sulfanyl]pyrimidin-4-ol (100 mg, 429 μmol) was stirred in methanol (10 mL) and a solution of HCl 4N in dioxane (160 μL, 643 mmol) was added dropwise at 0° C. The mixture was stirred for 30 minutes at room temperature. The solvent was removed, and the residue was washed 3 times with diethyl ether and dried in vacuo to afford to 6-methyl-2-[(pyridin-4-ylmethyl)sulfanyl]pyrimidin-4-ol hydrochloride (109 mg, 94% yield); 1H NMR (400 MHz, MeOd4): δ 2.42 (s, 3H), 4.82 (s, 2H), 6.48 (s, 1H), 8.26 (bs, 2H), 8.82 (bs, 2H); LRMS (ES+) m/z 234 (100%, M+1).

1. customThe solvent was removed
2. washthe residue was washed 3 times with diethyl ether
3. customdried in vacuo