Hydrochloric Acid → HCID 68987419, compound

HRID 57695Notes

Reaction equation

HRID 57695 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH:9]2[CH2:14][CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]2)[CH:5]=[CH:4][C:3]=1[N+:22]([O-:24])=[O:23].[ClH:25]>O1CCOCC1>[ClH:25].[N+:22]([C:3]1[C:2]([NH2:1])=[N:7][C:6]([NH:8][CH:9]2[CH2:14][CH2:13][CH2:12][NH:11][CH2:10]2)=[CH:5][CH:4]=1)([O-:24])=[O:23]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57911762Tert-butyl 3-[(6-amino-5-nitropyridin-2-yl)amino]piperidine-1-carboxylate

Product 1

HCID 68987419HCID 68987419, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

610 mg (1.62 mmol) of tert-butyl 3-[(6-amino-5-nitropyridin-2-yl)amino]piperidine-1-carboxylate (Example 41A) were dissolved in 40 ml of a solution of hydrochloric acid in dioxane (4 M), and the mixture was stirred at RT for 30 min. After the reaction had gone to completion, the solvent was removed completely. This gave 662 mg of the crude product.

Workup

  1. customthe solvent was removed completely

Sources & evidence

ORD record
ord-1e6f8c9dce6349a0a5f890474888c92b
Source dataset
uspto-grants-2016_09
Patent number
US09434731B2

Reaction notes

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