3-Aminopiperidine hydrochloride, N1-BOC protected → HCID 59313133, compound

HRID 57697Notes

Reaction equation

HRID 57697 reaction equation
Cl.[NH2:2][CH:3]1[CH2:8][CH2:7][CH2:6][N:5]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:4]1.[NH2:16][C:17]1[N:18]=[C:19](S(C)(=O)=O)[S:20][C:21]=1[C:22]([O:24][CH3:25])=[O:23]>>[NH2:16][C:17]1[N:18]=[C:19]([NH:2][CH:3]2[CH2:8][CH2:7][CH2:6][N:5]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:4]2)[S:20][C:21]=1[C:22]([O:24][CH3:25])=[O:23]

Participants

3

Reactant 2

HCID 177503343-Aminopiperidine hydrochloride, N1-BOC protectedHCID 59511825Methyl 4-amino-2-(methylsulfonyl)thiazole-5-carboxylate

Product 1

HCID 59313133HCID 59313133, compound

Procedure

Analogously to the preparation of Example 49A, 335 mg (1.42 mmol) of tert-butyl 3-aminopiperidine-1-carboxylate hydrochloride and 3190 mg (2.84 mmol) of methyl 4-amino-2-(methylsulfonyl)-1,3-thiazole-5-carboxylate gave 158 mg (29% of theory) of the product as a solid.

Sources & evidence

ORD record
ord-ba12e22605c74247aeb673a492175696
Source dataset
uspto-grants-2016_09
Patent number
US09434731B2

Reaction notes

Loading…