HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-[4-Amino-2-(piperidin-3-ylamino)-1,3-thiazol-5-yl]ethanone dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 59313134 | HCID 59313134 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-[4-Amino-2-(piperidin-3-ylamino)-1,3-thiazol-5-yl]ethanone dihydrochloride | HCID 86651627 | — |
Reaction Steps
Analogously to the preparation of Example 38A, 160 mg (0.15 mmol) of tert-butyl 3-[(5-acetyl-4-amino-1,3-thiazol-2-yl)amino]piperidine-1-carboxylate (Example 49A) and 20 ml of hydrochloric acid in dioxane (4M) gave 40 mg (87% of theory) of the product as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434731B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-f57c7582a04d49da8bafc63ef6c01870 |
| Source note | uspto-grants-2016_09 |