Hydrochloric Acid → 1-[4-Amino-2-(piperidin-3-ylamino)-1,3-thiazol-5-yl]ethanone dihydrochloride

HRID 57703Notes

Reaction equation

HRID 57703 reaction equation
[C:1]([C:4]1[S:8][C:7]([NH:9][CH:10]2[CH2:15][CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11]2)=[N:6][C:5]=1[NH2:23])(=[O:3])[CH3:2].[ClH:24]>O1CCOCC1>[ClH:24].[ClH:24].[NH2:23][C:5]1[N:6]=[C:7]([NH:9][CH:10]2[CH2:15][CH2:14][CH2:13][NH:12][CH2:11]2)[S:8][C:4]=1[C:1](=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59313134HCID 59313134, compound

Product 1

HCID 866516271-[4-Amino-2-(piperidin-3-ylamino)-1,3-thiazol-5-yl]ethanone dihydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Analogously to the preparation of Example 38A, 160 mg (0.15 mmol) of tert-butyl 3-[(5-acetyl-4-amino-1,3-thiazol-2-yl)amino]piperidine-1-carboxylate (Example 49A) and 20 ml of hydrochloric acid in dioxane (4M) gave 40 mg (87% of theory) of the product as a solid.

Sources & evidence

ORD record
ord-f57c7582a04d49da8bafc63ef6c01870
Source dataset
uspto-grants-2016_09
Patent number
US09434731B2

Reaction notes

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