HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 577262Generated: October 28, 2026
Hydrochloric Acid → N-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine
https://huagongshe.com/reaction/577262
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-methyl-1H-pyrazol-4-amine | HCID 4770990 | — |
| Reactant | 6-chloro-1H-pyrazolo[3,4-d]pyrimidine | HCID 52911254 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | N-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine | HCID 66765655 | — |
Reaction Steps
A suspension of 1-methyl-1H-pyrazol-4-amine (1 eq), 6-chloro-1H-pyrazolo[3,4-d]pyrimidine (1 eq) and HCl (4 eq) in isopropanol was heated in the microwave at 140° C. for 1 h. After cooling to rt, the mixture was filtered and the resulting solid washed with cold isopropanol and diethyl ether to give N-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09040545B2 |
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| Source dataset | uspto-grants-2015_05 |
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| ORD ID | ord-972c328ddf594247a539556e8438105d |
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| Source note | uspto-grants-2015_05 |
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