反应详情

温度

140 °C

A suspension of 1-methyl-1H-pyrazol-4-amine (1 eq), 6-chloro-1H-pyrazolo[3,4-d]pyrimidine (1 eq) and HCl (4 eq) in isopropanol was heated in the microwave at 140° C. for 1 h. After cooling to rt, the mixture was filtered and the resulting solid washed with cold isopropanol and diethyl ether to give N-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine.

1. temperatureAfter cooling to rt
2. filtrationthe mixture was filtered
3. washthe resulting solid washed with cold isopropanol and diethyl ether