Hydrochloric Acid → N-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine

HRID 577262Notes

Reaction equation

HRID 577262 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([NH2:7])[CH:4]=[N:3]1.Cl[C:9]1[N:14]=[C:13]2[NH:15][N:16]=[CH:17][C:12]2=[CH:11][N:10]=1.Cl>C(O)(C)C>[CH3:1][N:2]1[CH:6]=[C:5]([NH:7][C:9]2[N:14]=[C:13]3[NH:15][N:16]=[CH:17][C:12]3=[CH:11][N:10]=2)[CH:4]=[N:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 47709901-methyl-1H-pyrazol-4-amineHCID 529112546-chloro-1H-pyrazolo[3,4-d]pyrimidine

Product 1

HCID 66765655N-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
140 °C

Procedure

A suspension of 1-methyl-1H-pyrazol-4-amine (1 eq), 6-chloro-1H-pyrazolo[3,4-d]pyrimidine (1 eq) and HCl (4 eq) in isopropanol was heated in the microwave at 140° C. for 1 h. After cooling to rt, the mixture was filtered and the resulting solid washed with cold isopropanol and diethyl ether to give N-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine.

Workup

  1. temperatureAfter cooling to rt
  2. filtrationthe mixture was filtered
  3. washthe resulting solid washed with cold isopropanol and diethyl ether

Sources & evidence

ORD record
ord-972c328ddf594247a539556e8438105d
Source dataset
uspto-grants-2015_05
Patent number
US09040545B2

Reaction notes

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