Tert-butyl 3-oxopiperazine-1-carboxylate → HCID 66764735, compound

HRID 577288Notes

Reaction equation

HRID 577288 reaction equation
Br[C:2]1[CH:3]=[C:4]([F:11])[C:5]([F:10])=[C:6]([CH2:8][OH:9])[CH:7]=1.[O:12]=[C:13]1[NH:18][CH2:17][CH2:16][N:15]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:14]1>>[F:11][C:4]1[CH:3]=[C:2]([N:18]2[CH2:17][CH2:16][N:15]([C:19]([O:21][C:22]([CH3:24])([CH3:23])[CH3:25])=[O:20])[CH2:14][C:13]2=[O:12])[CH:7]=[C:6]([CH2:8][OH:9])[C:5]=1[F:10]

Participants

3

Reactant 2

HCID 3157178Tert-butyl 3-oxopiperazine-1-carboxylateHCID 40427031(5-bromo-2,3-difluorophenyl)methanol

Product 1

HCID 66764735HCID 66764735, compound

Procedure

tert-butyl 4-(3,4-difluoro-5-(hydroxymethyl)phenyl)-3-oxopiperazine-1-carboxylate was prepared following the procedure in Example 27 (Step ii) using (5-bromo-2,3-difluorophenyl)methanol and tert-butyl 3-oxopiperazine-1-carboxylate.

Sources & evidence

ORD record
ord-315e90c16893400e9c9952cf238fc046
Source dataset
uspto-grants-2015_05
Patent number
US09040545B2

Reaction notes

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