Benzenamine, 4-(4-morpholinyl)- → HCID 59491780, compound

HRID 577405Notes

Reaction equation

HRID 577405 reaction equation
[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([S:12][C:13]3[CH:18]=[CH:17][N:16]=[C:15](Cl)[N:14]=3)=[CH:8][CH:7]=2)[CH:5]=[N:4][N:3]=[N:2]1.[O:20]1[CH2:25][CH2:24][N:23]([C:26]2[CH:32]=[CH:31][C:29]([NH2:30])=[CH:28][CH:27]=2)[CH2:22][CH2:21]1>>[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([S:12][C:13]3[CH:18]=[CH:17][N:16]=[C:15]([NH:30][C:29]4[CH:28]=[CH:27][C:26]([N:23]5[CH2:24][CH2:25][O:20][CH2:21][CH2:22]5)=[CH:32][CH:31]=4)[N:14]=3)=[CH:8][CH:7]=2)[CH:5]=[N:4][N:3]=[N:2]1

Participants

3

Reactant 2

HCID 75655Benzenamine, 4-(4-morpholinyl)-HCID 866455724-(4-(1H-tetrazol-1-yl)phenylthio)-2-chloropyrimidine

Product 1

HCID 59491780HCID 59491780, compoundYield 38.1%

Procedure

In a procedure analogous to Example 8, reaction of 4-(4-(1H-tetrazol-1-yl)phenylthio)-2-chloropyrimidine (100 mg, 0.34 mmol) and 4-morpholinoaniline (75 mg, 0.41 mmol) furnished the product (56 mg, 38%).

Sources & evidence

ORD record
ord-a2b21ef04ce5435e8bee13f67745494c
Source dataset
uspto-grants-2015_05
Patent number
US09040549B2

Reaction notes

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