Acrylic Acid → N-(4-(2-chloropyrimidin-4-ylthio)phenyl)acrylamide

HRID 577412Notes

Reaction equation

HRID 577412 reaction equation
ClC1N=C(C2C=CC(SN)=CC=2)C=CN=1.[Cl:16][C:17]1[N:22]=[C:21]([S:23][C:24]2[CH:29]=[CH:28][C:27]([NH2:30])=[CH:26][CH:25]=2)[CH:20]=[CH:19][N:18]=1.[C:31](O)(=[O:34])[CH:32]=[CH2:33]>>[Cl:16][C:17]1[N:22]=[C:21]([S:23][C:24]2[CH:25]=[CH:26][C:27]([NH:30][C:31](=[O:34])[CH:32]=[CH2:33])=[CH:28][CH:29]=2)[CH:20]=[CH:19][N:18]=1

Participants

3

Reactant 2

HCID 6581Acrylic AcidHCID 131731896HCID 131731896, compound

Product 1

HCID 86645568N-(4-(2-chloropyrimidin-4-ylthio)phenyl)acrylamideYield 56%

Procedure

In a procedure analogous to Example 15, reaction of 4-(2-chloropyrimidin-4-ylthio)benzenamine 2-chloro-4-(4′-aminothiophenyl)pyrimidine (800 mg, 3.37 mmol) and acrylic acid (463 μL, 6.74 mmol) furnished the product (550 mg, 56%).

Sources & evidence

ORD record
ord-1395b8747cca4448b5e21b7c656ebec2
Source dataset
uspto-grants-2015_05
Patent number
US09040549B2

Reaction notes

Loading…