4-(1,3-Oxazol-2-yl)aniline → HCID 86706426, compound

HRID 577433Notes

Reaction equation

HRID 577433 reaction equation
[O:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:12]=[CH:11][C:9]([NH2:10])=[CH:8][CH:7]=1.[NH2:13][C@H:14]1[CH2:19][CH2:18][CH2:17][CH2:16][C@H:15]1[NH:20][C:21]1[N:22]=[N:23][C:24]([C:40]([NH2:42])=[O:41])=[C:25](NC2C=CC=C(C3N=CC=CN=3)C=2)[N:26]=1>>[NH2:13][C@H:14]1[CH2:19][CH2:18][CH2:17][CH2:16][C@H:15]1[NH:20][C:21]1[N:22]=[N:23][C:24]([C:40]([NH2:42])=[O:41])=[C:25]([NH:10][C:9]2[CH:11]=[CH:12][C:6]([C:2]3[O:1][CH:5]=[CH:4][N:3]=3)=[CH:7][CH:8]=2)[N:26]=1

Participants

3

Reactant 2

HCID 123717394-(1,3-Oxazol-2-yl)anilineHCID 72703032HCID 72703032, compound

Product 1

HCID 86706426HCID 86706426, compound

Procedure

The title compound was prepared with 4-(oxazol-2-yl)aniline using the similar procedure described in Example 3-((1R,2S)-2-aminocyclohexylamino)-5-(3-(pyrimidin-2-yl)phenylamino)-1,2,4-triazine-6-carboxamide. MS found for C19H22N8O2 as (M+H)+ 395.6. UV: λ=240, 297 nm. Proton NMR: (CD3OD) δ 8.13 (2H, m), 8.03 (1H, s), 7.90 (2H, m), 7.34 (1H, s), 4.45 (1H, m), 3.72 (1H, m), 1.90-1.63 (8H, m) ppm.

Sources & evidence

ORD record
ord-10ecb08793ee4a6bb3321966e2906e47
Source dataset
uspto-grants-2015_05
Patent number
US09040530B2

Reaction notes

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