HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(1,3-Oxazol-2-yl)aniline → 3-(((1R,2S)-2-aminocyclohexyl)amino)-5-((4-(oxazol-2-yl)phenyl)amino)-1,2,4-triazine-6-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(1,3-Oxazol-2-yl)aniline | HCID 12371739 | — |
| Reactant | 3-((1R,2S)-2-aminocyclohexylamino)-5-(3-(pyrimidin-2-yl)phenylamino)-1,2,4-triazine-6-carboxamide | HCID 72703032 | — |
| Product | 3-(((1R,2S)-2-aminocyclohexyl)amino)-5-((4-(oxazol-2-yl)phenyl)amino)-1,2,4-triazine-6-carboxamide | HCID 86706426 | — |
Reaction Steps
The title compound was prepared with 4-(oxazol-2-yl)aniline using the similar procedure described in Example 3-((1R,2S)-2-aminocyclohexylamino)-5-(3-(pyrimidin-2-yl)phenylamino)-1,2,4-triazine-6-carboxamide. MS found for C19H22N8O2 as (M+H)+ 395.6. UV: λ=240, 297 nm. Proton NMR: (CD3OD) δ 8.13 (2H, m), 8.03 (1H, s), 7.90 (2H, m), 7.34 (1H, s), 4.45 (1H, m), 3.72 (1H, m), 1.90-1.63 (8H, m) ppm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09040530B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-10ecb08793ee4a6bb3321966e2906e47 |
| Source note | uspto-grants-2015_05 |