反应详情

温度

70 °C

Sodium (23 g, 0.99 mol) was added to dry MeOH (800 mL) portion-wise. After the addition, the mixture was stirred for an hour until the sodium was mostly dissolved. To the reaction mixture was added 2-chloro-4,6-dimethylpyridine-3-carbonitrile (110 g, 0.66 mol). The resulting mixture was heated at 70° C. and stirred for four hours. The suspension was filtered and the filtrate was concentrated under vacuum. The residue was purified by column chromatography (petroleum ether/EtOAc, 10:1) to give 2-methoxy-4,6-dimethylpyridine-3-carbonitrile (Cpd S, 103 g, 100%) as a white solid.

1. additionAfter the addition
2. dissolutionwas mostly dissolved
3. filtrationThe suspension was filtered
4. concentrationthe filtrate was concentrated under vacuum
5. customThe residue was purified by column chromatography (petroleum ether/EtOAc, 10:1)