Hydrogen Bromide → HCID 22499224, compound

HRID 577628Notes

Reaction equation

HRID 577628 reaction equation
[BrH:1].[OH:2][C:3]1[CH:4]=[C:5]([CH3:14])[CH:6]=[C:7]2[C:12]=1[NH:11][C:10](=[O:13])[CH:9]=[CH:8]2>C(O)(=O)C.CS(C)=O>[Br:1][C:6]1[C:5]([CH3:14])=[CH:4][C:3]([OH:2])=[C:12]2[C:7]=1[CH:8]=[CH:9][C:10](=[O:13])[NH:11]2

Participants

5

Reactant 2

HCID 260Hydrogen BromideHCID 22499171HCID 22499171, compound

Product 1

HCID 22499224HCID 22499224, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 679Dimethyl SulfoxideSolvent

Procedure

A 45% solution of hydrobromic acid in acetic acid (324 μL) is added dropwise to a solution of 8-hydroxy-6-methyl-1H-quinolin-2-one (316 mg) in dimethylsulphoxide (9 mL) at room temperature. The reaction mixture is allowed to stand for 18 hours at room temperature and the solvent removed in vacuo.

Workup

  1. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-e9e668f156ca48c4aed67bea3321b39c
Source dataset
uspto-grants-2015_05
Patent number
US09040559B2

Reaction notes

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