反应详情

To tert-butyl((trans)-3-((2-((1-methyl-1H-pyrazol-4-yl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)carbamate (115 mg, 0.218 mmol) in DCM (5 mL) was added 4 N HCl in 1,4-dioxane (0.3 mL, 1.2 mmol). The reaction was allowed to stir at rt for 3.5 hrs and then quenched with saturated aqueous NaHCO3 (2 mL). DCM (10 mL) was added and the DCM extract was dried over MgSO4, filtered and concentrated to afford the title compound (87 mg, 93% yield) as a tan foam.

1. customquenched with saturated aqueous NaHCO3 (2 mL)
2. additionDCM (10 mL) was added
3. extractionthe DCM extract
4. dry with materialwas dried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated