Hydrochloric Acid → HCID 178480792, compound

Participants

Reaction Steps

To tert-butyl((trans)-3-((2-((1-methyl-1H-pyrazol-4-yl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)carbamate (115 mg, 0.218 mmol) in DCM (5 mL) was added 4 N HCl in 1,4-dioxane (0.3 mL, 1.2 mmol). The reaction was allowed to stir at rt for 3.5 hrs and then quenched with saturated aqueous NaHCO3 (2 mL). DCM (10 mL) was added and the DCM extract was dried over MgSO4, filtered and concentrated to afford the title compound (87 mg, 93% yield) as a tan foam.

Provenance & Evidence