HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-methyl-1H-pyrazol-4-amine → HCID 178481025, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-methyl-1H-pyrazol-4-amine | HCID 4770990 | — |
| Reactant | N,N'-Di-Boc-1H-pyrazole-1-carboximidamide | HCID 6383521 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 178481025 | HCID 178481025 | 92.1% |
Reaction Steps
1-methyl-1H-pyrazol-4-amine (11.7 g, 0.12 mol) was added portion-wise to a solution of di-tert-butyl [(Z)-1H-pyrazol-1-ylmethylylidene]biscarbamate (17.5 g, 0.056 mol) in MeCN (100 mL). The mixture was stirred for 20 hrs then filtered to afford the title compound (17.5 g, 91% yield) as a crude solid which was used as is in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09040547B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-68a8f8744dc8457c9db76ab9237448e1 |
| Source note | uspto-grants-2015_05 |