反应详情

To a solution tert-butyl {trans-3-[(2-[(1-methyl-1H-pyrazol-4-yl)amino]-5-(pyridin-2-yl)-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]cyclobutyl}carbamate (359 mg, 0.592 mmol) in DCM (3 mL) was added trifluoroacetic acid (2 mL) and stirred at ambient temperature for 2 hrs. The reaction was concentrated down to a dark oil to give the title compound that was used as is for next step. m/z (ESI+) for C20H22N8O2 407.0 (M+H)+.

1. concentrationThe reaction was concentrated down to a dark oil