(4-Methoxyphenyl)boronic acid → 8-(4-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

HRID 57771Notes

Reaction equation

HRID 57771 reaction equation
FC(F)(F)[C:3]1[CH:4]=[C:5]([C:9]2[C:10]3[N:11]([N:15]=[C:16]([NH2:18])[N:17]=3)[CH:12]=[CH:13][CH:14]=2)[CH:6]=[CH:7][CH:8]=1.[CH3:21][O:22]C1C=CC(B(O)O)=CC=1>>[CH3:21][O:22][C:8]1[CH:7]=[CH:6][C:5]([C:9]2[C:10]3[N:11]([N:15]=[C:16]([NH2:18])[N:17]=3)[CH:12]=[CH:13][CH:14]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 201262(4-Methoxyphenyl)boronic acidHCID 591990748-(3-Trifluoromethylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Product 1

HCID 591990058-(4-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Procedure

Made by following the procedure described for the preparation of 8-(3-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine with 4-methoxyphenyl boronic acid and making non-critical variations.

Sources & evidence

ORD record
ord-c5f12971cb8a4f7694030a941dd2f8a3
Source dataset
uspto-grants-2016_09
Patent number
US09434732B2

Reaction notes

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