Pyridine → N-(2,5-dimethylpyrazol-3-yl)acetamide

HRID 577765Notes

Reaction equation

HRID 577765 reaction equation
N1C=CC=CC=1.[CH3:7][N:8]1[C:12]([NH2:13])=[CH:11][C:10]([CH3:14])=[N:9]1.[C:15](OC(=O)C)(=[O:17])[CH3:16]>>[CH3:7][N:8]1[C:12]([NH:13][C:15](=[O:17])[CH3:16])=[CH:11][C:10]([CH3:14])=[N:9]1

Participants

4

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 5207211,3-Dimethyl-1H-pyrazol-5-amine

Product 1

HCID 574162N-(2,5-dimethylpyrazol-3-yl)acetamideYield 100%

Procedure

Pyridine (7.1 mL, 90 mmol) was added to a solution of 2,5-dimethyl-2H-pyrazol-3-ylamine (10 g, 90 mmol) in acetic anhydride (46 mL) at 0° C. and the resulting mixture was stirred at room temperature for 30 min. The solvent was removed under vacuum to yield the title compound as a brownish liquid (13.7 g), yield: 100%.

Workup

  1. customThe solvent was removed under vacuum

Sources & evidence

ORD record
ord-1896fac15466418ea344d06333fbaa35
Source dataset
uspto-grants-2015_05
Patent number
US09040558B2

Reaction notes

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