Hydrochloric Acid → HCID 117853310, compound

HRID 57780Notes

Reaction equation

HRID 57780 reaction equation
[CH3:1][C:2]1[C:10]2[C:9]([O:11][CH2:12][C:13]3[O:17][N:16]=[C:15]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[CH:14]=3)=[N:8][CH:7]=[N:6][C:5]=2[S:4][CH:3]=1.[ClH:24]>CO>[ClH:24].[CH3:1][C:2]1[C:10]2[C:9]([O:11][CH2:12][C:13]3[O:17][N:16]=[C:15]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[CH:14]=3)=[N:8][CH:7]=[N:6][C:5]=2[S:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 734426745-Methyl-4-((3-phenyl-isoxazol-5-yl)-methoxy-)-thieno[2,3-d]pyrimidine

Product 1

HCID 117853310HCID 117853310, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.5 mmol of 5-methyl-4-((3-phenyl-isoxazol-5-yl)-methoxy-)-thieno[2,3-d]pyrimidine was added in 20 ml of 5% mixing solution of hydrochloric acid solution and methanol (V:V, 1:1). Then the mixture was dissolved under stirring with slightly heating and slowly evaporated at room temperature to afford 5-methyl-4-((3-phenyl-isoxazol-5-yl)-methoxy-)-thieno[2,3-d]pyrimidine hydrochloride as a white solid in 72% yield.

Workup

  1. dissolutionThen the mixture was dissolved
  2. temperaturewith slightly heating
  3. customslowly evaporated at room temperature

Sources & evidence

ORD record
ord-d5b36bfa9de84addaed97ceac6456e62
Source dataset
uspto-grants-2016_09
Patent number
US09434741B2

Reaction notes

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