Hydrazine hydrate (1:1) → HCID 178507271, compound
Reaction equation
[CH:1]1([C:6](=O)[CH2:7][C:8]#[N:9])[CH2:5][CH2:4][CH2:3][CH2:2]1.O.[NH2:12][NH2:13]>C(O)C>[CH:1]1([C:6]2[CH:7]=[C:8]([NH2:9])[NH:12][N:13]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
To a solution of 3-cyclopentyl-3-oxo-propionitrile (1.0 g, 7.3 mmol, 1 eq) in ethanol (10 mL) was added a 64 wt.-% solution of hydrazine hydrate (1.1 mL, 14.6 mmol, 2 eq). The mixture was heated at 80° C. for 16 h and was evaporated to dryness. The residue was purified by flash chromatography using dichloromethane and methanol (100/0 to 90/10) to afford 5-cyclopentyl-2H-pyrazol-3-ylamine as yellow oil (510 mg, 46% yield).
Workup
- customwas evaporated to dryness
- customThe residue was purified by flash chromatography
Sources & evidence
- ORD record
- ord-f508e5e6d1694f36aff25ab4b487bb59
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09434745B2
Reaction notes
Loading…