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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 577939Generated: October 28, 2026

3-Cyanobenzylamine hydrochloride → 5-((tert-Butyldiphenylsilyloxy)methyl)-7-chloro-N-(3-cyanobenzyl)-6-((2R,6S)-2,6-dimethylmorpholino)isoxazolo[4,5-b]pyridine-3-carboxamide

https://huagongshe.com/reaction/577939

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Cyanobenzylamine hydrochlorideHCID 23509298—
ReactantEthyl 5-((tert-butyldiphenylsilyloxy)methyl)-7-chloro-6-((2R,6S)-2,6-dimethylmorpholino)isoxazolo[4,5-b]pyridine-3-carboxylateHCID 67356857—
Product5-((tert-Butyldiphenylsilyloxy)methyl)-7-chloro-N-(3-cyanobenzyl)-6-((2R,6S)-2,6-dimethylmorpholino)isoxazolo[4,5-b]pyridine-3-carboxamideHCID 67358444—

Reaction Steps

Starting materials: ethyl 5-((tert-butyldiphenylsilyloxy)methyl)-7-chloro-6-((2R,6S)-2,6-dimethylmorpholino)isoxazolo[4,5-b]pyridine-3-carboxylate (Intermediate 211) and 3-(aminomethyl)benzonitrile-HCl.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09040528B2
Source datasetuspto-grants-2015_05
ORD IDord-8988936e3e6d4868ba10168873d0229c
Source noteuspto-grants-2015_05