Propylene Oxide → HCID 67358844, compound

HRID 577979Notes

Reaction equation

HRID 577979 reaction equation
[CH2:1]([NH:8][CH2:9][CH:10]([OH:13])[CH2:11][CH3:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:14]1[O:17][CH:15]1[CH3:16]>C(O)C>[CH2:1]([N:8]([CH2:14][CH:15]([OH:17])[CH3:16])[CH2:9][CH:10]([OH:13])[CH2:11][CH3:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6378Propylene OxideHCID 131634581-[(Phenylmethyl)amino]-2-butanol2×

Product 1

HCID 67358844HCID 67358844, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
150 °C

Procedure

To a solution of 1-benzylamino-butan-2-ol (Intermediate 482, 8.5 g, 47.48 mmol) in ethanol (150 mL) was added propylene oxide (8.8 g, 151 mmole) and the mixture was heated at 150° C. for 2 h in autoclave. After concentration of the mixture under reduced pressure, the residue was purified by column chromatography using methanol in dichloromethane to give product as an oil.

Workup

  1. customAfter concentration of the mixture under reduced pressure, the residue was purified by column chromatography
  2. customto give product as an oil

Sources & evidence

ORD record
ord-68bb673bb5294cd8b4fc0b81a29fe82e
Source dataset
uspto-grants-2015_05
Patent number
US09040528B2

Reaction notes

Loading…