trans-2,6-Dimethylmorpholine → 6-((2R,6R)-2,6-dimethylmorpholino)-7-fluoro-3-methylbenzo[d]isoxazole-5-carbaldehyde

HRID 577994Notes

Reaction equation

HRID 577994 reaction equation
F[C:2]1[C:11]([CH:12]=[O:13])=[CH:10][C:5]2[C:6]([CH3:9])=[N:7][O:8][C:4]=2[C:3]=1[F:14].[CH3:15][C@H:16]1[O:21][C@H:20]([CH3:22])[CH2:19][NH:18][CH2:17]1>>[CH3:22][C@@H:20]1[CH2:19][N:18]([C:2]2[C:11]([CH:12]=[O:13])=[CH:10][C:5]3[C:6]([CH3:9])=[N:7][O:8][C:4]=3[C:3]=2[F:14])[CH2:17][C@@H:16]([CH3:15])[O:21]1

Participants

3

Reactant 2

HCID 11137133trans-2,6-DimethylmorpholineHCID 86658113HCID 86658113, compound2×

Product 1

HCID 866581236-((2R,6R)-2,6-dimethylmorpholino)-7-fluoro-3-methylbenzo[d]isoxazole-5-carbaldehyde

Procedure

Starting materials: 6,7-difluoro-3-methylbenzo[d]isoxazole-5-carbaldehyde (Intermediate 374) and (2R,6R)-2,6-dimethylmorpholine.

Sources & evidence

ORD record
ord-6947d48bd9794d08bde4867668ae13ff
Source dataset
uspto-grants-2015_05
Patent number
US09040528B2

Reaction notes

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