Hydrochloric Acid → HCID 67432356, compound

HRID 578037Notes

Reaction equation

HRID 578037 reaction equation
[F:1][C:2]1[C:3]2[O:28][N:27]=[C:26]([N:29]3[CH2:34][CH2:33][N:32](C(OC(C)(C)C)=O)[CH2:31][CH2:30]3)[C:4]=2[CH:5]=[C:6]2[C:19]=1[N:18]1[CH2:20][C@@H:21]([CH3:25])[O:22][C@@H:23]([CH3:24])[C@@H:17]1[C:8]1([C:13](=[O:14])[NH:12][C:11](=[O:15])[NH:10][C:9]1=[O:16])[CH2:7]2.Cl>CO>[F:1][C:2]1[C:3]2[O:28][N:27]=[C:26]([N:29]3[CH2:30][CH2:31][NH:32][CH2:33][CH2:34]3)[C:4]=2[CH:5]=[C:6]2[C:19]=1[N:18]1[CH2:20][C@@H:21]([CH3:25])[O:22][C@@H:23]([CH3:24])[C@@H:17]1[C:8]1([C:13](=[O:14])[NH:12][C:11](=[O:15])[NH:10][C:9]1=[O:16])[CH2:7]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 45381786HCID 45381786, compound

Product 1

HCID 67432356HCID 67432356, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of tert-butyl 4-[(2R,4S,4aS)-rel-11-fluoro-2,4-dimethyl-2′,4′,6′-trioxo-1,1′,2,3′,4,4′,4a,6′-octahydro-2′H,6H-spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5,5′-pyrimidin]-8-yl]piperazine-1-carboxylate (Example 20, 50 mg, 0.08 mmol) and 4N HCl in MeOH (8 mL) was stirred at room temperature for 1 hours. It was concentrated under reduced pressure and the residue was triturated with pet ether to give the title compound as brown solid.

Workup

  1. concentrationIt was concentrated under reduced pressure
  2. customthe residue was triturated with pet ether

Sources & evidence

ORD record
ord-a91e7c81169e4ddc84619cd6a07b717f
Source dataset
uspto-grants-2015_05
Patent number
US09040528B2

Reaction notes

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