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HRID578038

反应详情

EQUATION

反应方程式

HRID 578038 的结构方程式

REACTANTS

反应物

2
结构：O=C1CC(=O)NC(=O)N1
HCID6211

Barbituric acid

C4H4N2O3

结构：C[C@@H]1CN(c2c(C=O)cc3c(Cl)noc3c2F)C[C@@H](C)O1
HCID86658122

未命名化合物

2 次

PRODUCTS

生成物

1
结构：C[C@@H]1CN2c3c(cc4c(Cl)noc4c3F)CC3(C(=O)NC(=O)NC3=O)[C@H]2[C@H](C)O1
HCID67432893

未命名化合物

收率 26.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

A mixture of 3-chloro-6-((2R,6R)-2,6-dimethylmorpholino)-7-fluorobenzo[d]isoxazole-5-carbaldehyde (Intermediate 535, 764 mg, 2.44 mmol) and pyrimidine-2,4,6(1H,3H,5H)-trione (313 mg, 2.44 mmol) in iPrOH (3 ml) was heated at reflux for 3 days. Solvent was removed and the residue was recrystallized from methanol. The solids obtained were recrystallized from 1:1 EtOH-Water to afford 273 mg of product consistent with desired product.

WORKUP

后处理

  1. temperaturewas heated
  2. temperatureat reflux for 3 days
  3. customSolvent was removed
  4. customthe residue was recrystallized from methanol
  5. customThe solids obtained
  6. customwere recrystallized from 1:1 EtOH-Water