反应详情

Palladium on charcoal (3.50 g 10%) was added to the product obtained at (655c) (16.7 g, 46.1 mmol) in 200 mL THF with 200 mL ethanol and the mixture was hydrogenated using a Parr apparatur at 60 psi H2 pressure and 50° C. for 3 h. The mixture was filtered, washed with ethanol and the filtrate concentrated i. vac. The residue was triturated with dichloromethane and evaporated to dryness. The product was reacted without further purification.

1. customat 60 psi H2 pressure and 50° C.
2. customfor 3 h
3. filtrationThe mixture was filtered
4. washwashed with ethanol
5. concentrationthe filtrate concentrated i
6. customThe residue was triturated with dichloromethane
7. customevaporated to dryness
8. customThe product was reacted without further purification