HCID 86665216, compound → HCID 86665217, compound

HRID 578060Notes

Reaction equation

HRID 578060 reaction equation
[NH2:1][C:2]1[C:23]([N+:24]([O-])=O)=[CH:22][C:5]([C:6]([NH:8][C:9]2[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[C:11]([N:19]([CH3:21])[CH3:20])[N:10]=2)=[O:7])=[C:4]([O:27][CH2:28][C:29]([F:32])([F:31])[F:30])[CH:3]=1>[Pd].C1COCC1.C(O)C>[NH2:1][C:2]1[C:23]([NH2:24])=[CH:22][C:5]([C:6]([NH:8][C:9]2[CH:14]=[C:13]([C:15]([F:17])([F:18])[F:16])[CH:12]=[C:11]([N:19]([CH3:21])[CH3:20])[N:10]=2)=[O:7])=[C:4]([O:27][CH2:28][C:29]([F:32])([F:30])[F:31])[CH:3]=1

Participants

5

Reactant 1

HCID 86665216HCID 86665216, compound

Product 1

HCID 86665217HCID 86665217, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to example 655d by hydrogenation of the product obtained in 656c with palladium on charcoal in THF and ethanol.

Workup

  1. customPrepared analogously to example 655d by hydrogenation of the product

Sources & evidence

ORD record
ord-1e25ce3692e2489d95e7a8949efde8d0
Source dataset
uspto-grants-2015_05
Patent number
US09040565B2

Reaction notes

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