Ammonia → Ethyl 4-amino-2-fluoro-5-nitrobenzoate

HRID 578065Notes

Reaction equation

HRID 578065 reaction equation

[F:1][C:2]1[CH:12]=[C:11](F)[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[NH3:17]>C1COCC1>[NH2:17][C:11]1[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])=[C:2]([F:1])[CH:12]=1

Participants

4

Reactant 2

HCID 222Ammonia

HCID 22330120Ethyl 2,4-difluoro-5-nitrobenzoate

Product 1

HCID 59529828Ethyl 4-amino-2-fluoro-5-nitrobenzoate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to example 659a from ethyl 2,4-difluoro-5-nitro-benzoate and ammonia in THF.

Sources & evidence

ORD record: ord-530c8ba73c8c4ffdac6bae7c5736416c
Source dataset: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09040565B2

Reaction notes

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