HCID 67232682, compound → HCID 67232135, compound

HRID 578073Notes

Reaction equation

HRID 578073 reaction equation
[NH2:1][C:2]1[C:3]([N+:25]([O-])=O)=[CH:4][C:5]([O:21][CH:22]([F:24])[F:23])=[C:6]([CH:20]=1)[C:7]([NH:9][C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][N:11]=1)=[O:8]>[Pd].CO.C1COCC1>[NH2:25][C:3]1[C:2]([NH2:1])=[CH:20][C:6]([C:7]([NH:9][C:10]2[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][N:11]=2)=[O:8])=[C:5]([O:21][CH:22]([F:23])[F:24])[CH:4]=1

Participants

5

Reactant 1

HCID 67232682HCID 67232682, compound

Product 1

HCID 67232135HCID 67232135, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to example 655d by hydrogenation of the product obtained from (702a) using palladium on charcoal in methanol and THF.

Workup

  1. customPrepared analogously to example 655d by hydrogenation of the product

Sources & evidence

ORD record
ord-28e5941526754ef097e831d566deb916
Source dataset
uspto-grants-2015_05
Patent number
US09040565B2

Reaction notes

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