1,4-Diazepan-6-ol → 1-(6-(6-(5-ethylpyridin-3-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl)pyridin-2-yl)-1,4-diazepan-6-ol

HRID 57811Notes

Reaction equation

HRID 57811 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([C:9]2[N:14]=[CH:13][C:12]3[CH:15]=[N:16][N:17]([C:18]4[CH:23]=[CH:22][CH:21]=[C:20](F)[N:19]=4)[C:11]=3[CH:10]=2)[CH:6]=[N:7][CH:8]=1)[CH3:2].[NH:25]1[CH2:31][CH:30]([OH:32])[CH2:29][NH:28][CH2:27][CH2:26]1>>[CH2:1]([C:3]1[CH:4]=[C:5]([C:9]2[N:14]=[CH:13][C:12]3[CH:15]=[N:16][N:17]([C:18]4[N:19]=[C:20]([N:25]5[CH2:31][CH:30]([OH:32])[CH2:29][NH:28][CH2:27][CH2:26]5)[CH:21]=[CH:22][CH:23]=4)[C:11]=3[CH:10]=2)[CH:6]=[N:7][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 211142751,4-Diazepan-6-olHCID 867070186-(5-ethylpyridin-3-yl)-1-(6-fluoropyridin-2-yl)-1H-pyrazolo[4,3-c]pyridine

Product 1

HCID 727150461-(6-(6-(5-ethylpyridin-3-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl)pyridin-2-yl)-1,4-diazepan-6-olYield 12%

Procedure

Following the procedures as described in EXAMPLE 8 and starting with 6-(5-ethylpyridin-3-yl)-1-(6-fluoropyridin-2-yl)-1H-pyrazolo[4,3-c]pyridine and 1,4-diazepan-6-ol, 106 was obtained as an off-white solid (49.4 mg, 12%). MS (ESI) m/z: 416.1 [M+H]+

Sources & evidence

ORD record
ord-52908b37ccd9450c8a307710dde7efcd
Source dataset
uspto-grants-2016_09
Patent number
US09434725B2

Reaction notes

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