Ammonia → 3-(Methylsulfamoyl)benzoic acid

反応式

Cl[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].[CH3:14][NH2:15].N>>[CH3:14][NH:15][S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3]

参加物

反応物 3

HCID 222Ammonia

HCID 6329Methylamine

HCID 77641Benzoic acid, 3-(chlorosulfonyl)-

生成物 1

HCID 2526543-(Methylsulfamoyl)benzoic acid

実験手順

The title compound was prepared according to the procedure of Example 50A using 3-(chlorosulfonyl)benzoic acid (Aldrich) and methylamine (Aldrich). 1H NMR (300 MHz, CD3OD) δ 2.54 (s, 3H), 7.70 (t, J=7.8 Hz, 1H), 8.02-8.07 (m, 1H), 8.23-8.28 (m, 1H), 8.45 (t, J=1.9 Hz, 1H) ppm; MS (DCI/NH3) m/z 233 (M+NH4)+.

出典と根拠

ORDレコード: ord-923d78e90ce9427b8992c6633b2c2765
出典データセット: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09040568B2

反応ノート

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