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Ammonia → 3-(Pyridazin-4-yl)-5-(3,4,5-trifluorophenyl)-1,2,4-oxadiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 3,4,5-Trifluorobenzoyl chloride | HCID 2777023 | — |
| 反応物 | N-Hydroxy-4-pyridazinecarboximidamide | HCID 136140373 | — |
| 生成物 | 3-(Pyridazin-4-yl)-5-(3,4,5-trifluorophenyl)-1,2,4-oxadiazole | HCID 44544768 | — |
反応手順
The titled compound was prepared according to the procedure of Method D using the product of Example 83D and 3,4,5-trifluorobenzoyl chloride (Aldrich). 1H NMR (300 MHz, CD3OD) δ 8.04-8.16 (m, 2H), 8.38 (dd, J=5.4, 2.2 Hz, 1H), 9.46 (dd, J=5.4, 1.4 Hz, 1H), 9.86 (dd, J=2.4, 1.2 Hz, 1H) ppm; MS (DCI/NH3) m/z=279 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09040568B2 |
| 出典データセット | uspto-grants-2015_05 |
| ORD ID | ord-159fa2566383426597bdf00042e72397 |
| 出典メモ | uspto-grants-2015_05 |