Ammonia → HCID 44545068, compound

HRID 578183Notes

Reaction equation

HRID 578183 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10]([OH:12])=O)=[CH:7][CH:8]=2)[CH:3]=[N:2]1.O[N:14]=[C:15]([NH2:22])[C:16]1[CH:21]=[CH:20][CH:19]=[N:18][CH:17]=1.N>>[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10]3[O:12][N:22]=[C:15]([C:16]4[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=4)[N:14]=3)=[CH:7][CH:8]=2)[CH:3]=[N:2]1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 308113N-HydroxynicotinimidamideHCID 42484541H-Indazole-5-carboxylic acid

Product 1

HCID 44545068HCID 44545068, compound

Procedure

The title compound was prepared according to Method C using 1H-indazole-5-carboxylic acid (ABCR) and N′-hydroxynicotinimidamide (Tyger). 1H NMR (300 MHz, DMSO-d6) δ 7.7 (dd, J=7.9, 4.8 Hz, 1H), 7.8 (d, J=8.7 Hz, 1H), 8.2 (dd, J=8.7, 1.6 Hz, 1H), 8.4 (s, 1H) 8.5 (dt, J=7.9, 1.8 Hz, 1H), 8.7 (s, 1H) 8.8 (dd, J=4.8, 1.6 Hz, 1H), 9.3 (d, J=2.0 Hz, 1H), 13.6 (s, 1H) ppm; MS (DCI/NH3) m/z 264 (M+H)+.

Sources & evidence

ORD record
ord-7fcda079d2ea4615b6694fb8982b2a9b
Source dataset
uspto-grants-2015_05
Patent number
US09040568B2

Reaction notes

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