反应详情

To a solution of tert-butyl 4-[6-(6-pyrazin-2-ylpyrazolo[4,3-c]pyridin-1-yl)-2-pyridyl]piperazine-1-carboxylate (30 mg, 0.065 mmol) in hydrogen chloride (4 mol/l) in 1,4-dioxane (1.5 ml, 6.0 mmol) and 1,4-dioxane; 1.5 mL was stirred at RT 18 h. The reaction was concentrated and submitted for reverse phase HPLC to give 144 (12 mg) in 34% yield. MS (ESI) m/z: 359.1. 1H NMR (400 MHz, DMSO) δ 9.70 (s, 1H), 9.65 (d, J=1.1 Hz, 1H), 9.34 (s, 1H), 8.78-8.74 (m, 1H), 8.72 (d, J=2.4 Hz, 1H), 8.68 (d, J=5.3 Hz, 1H), 7.77 (t, J=8.1 Hz, 1H), 7.25 (d, J=7.7 Hz, 1H), 6.79 (d, J=8.4 Hz, 1H), 3.67-3.61 (m, 4H), 2.97-2.90 (m, 4H).

1. concentrationThe reaction was concentrated