反应详情

温度

25 °C

{circle around (1)} 100 g (0.49 mol) of 3-chloro-2-para-tolylpyridine was dissolved in 1 L of 1,4-dioxane in a reactor. 163.4 g (1.47 mol) of selenium dioxide was added, and the mixture was refluxed for 4˜6 hours. The reaction solution was cooled to 25° C., and floating matter was filtered off with celite. A 10% sodium bicarbonate solution was added, and the mixture was extracted with ethyl acetate. The organic layer was dried with magnesium sulfate, and concentrated under reduced pressure, yielding 4-(3-chloropyridin-2-yl)benzaldehyde as represented below in a 85% yield.

1. temperaturethe mixture was refluxed for 4˜6 hours
2. filtrationwas filtered off with celite
3. additionA 10% sodium bicarbonate solution was added
4. extractionthe mixture was extracted with ethyl acetate
5. dry with materialThe organic layer was dried with magnesium sulfate
6. concentrationconcentrated under reduced pressure