Water → tert-butyl 4-[6-(6-chloropyrazolo[4,3-c]pyridin-1-yl)-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxylate

HRID 57861Notes

Reaction equation

Br[C:2]1[N:7]=[C:6]([N:8]2[C:16]3[CH:15]=[C:14]([Cl:17])[N:13]=[CH:12][C:11]=3[CH:10]=[N:9]2)[CH:5]=[CH:4][CH:3]=1.[C:18]([O:22][C:23]([N:25]1[CH2:30][CH:29]=[C:28](B2OC(C)(C)C(C)(C)O2)[CH2:27][CH2:26]1)=[O:24])([CH3:21])([CH3:20])[CH3:19].C([O-])(=O)C.[K+].O>C(#N)C.C(=O)([O-])[O-].[Na+].[Na+].C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>[Cl:17][C:14]1[N:13]=[CH:12][C:11]2[CH:10]=[N:9][N:8]([C:6]3[N:7]=[C:2]([C:28]4[CH2:29][CH2:30][N:25]([C:23]([O:22][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:24])[CH2:26][CH:27]=4)[CH:3]=[CH:4][CH:5]=3)[C:16]=2[CH:15]=1

Participants

Conditions

Temperature: 95 °C

Procedure

To a solution of 1-(6-bromo-2-pyridyl)-6-chloro-pyrazolo[4,3-c]pyridine (150 mg, 0.485 mmol), 4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-3,6-dihydro-2 h-pyridine-1-carboxylic acid tert-butyl ester (180 mg, 0.581 mmol), and 1,1′-Bis(diphenylphosphino)ferrocenepalladium(II) chloride (32 mg, 0.039 mmol) in Acetonitrile 5.0 mL was added 1.00 M of Potassium acetate in Water (0.73 mL, 0.73 mmol) and 1.00 M of Sodium carbonate in Water (0.73 mL, 0.73 mmol). The reaction mixture was stirred at 95° C. for 2 h. The reaction was filtered through celite. The crude product was purified by flash chromatography (EtOAc/Heptane eluted at 35% EtOAc) to give tert-butyl 4-[6-(6-chloropyrazolo[4,3-c]pyridin-1-yl)-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxylate (185 mg) in 92% yield. MS (ESI) m/z: 412.2

Workup

filtrationThe reaction was filtered through celite
customThe crude product was purified by flash chromatography (EtOAc/Heptane eluted at 35% EtOAc)

Sources & evidence

ORD record: ord-68387a411fef4603b96d370ac08a4a3c
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09434725B2

Reaction notes

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