反应详情

温度

145 °C

A solution of tert-butyl 4-[6-(6-chloropyrazolo[4,3-c]pyridin-1-yl)-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxylate (200 mg, 0.486 mmol) and palladium(0)tetrakis(triphenylphosphine) (56 mg, 0.049 mmol) in N,N-dimethylacetamide 5.0 mL was added trimethyl-(6-methylpyrazin-2-yl)stannane (250 mg, 0.971 mmol). The reaction mixture heated at 145° C. for 40 min in microwave. The reaction mixture was filtered through celite and concentrated. The crude product was diluted with EtOAc then washed with water. The organic layers was dried with sodium sulfate, filtered, and concentrated in vacuum. The crude product was purified by flash chromatography (EtOAc/Heptane eluted at 65% EtOAc) to give the desired product 165 mg 72% yield.

1. filtrationThe reaction mixture was filtered through celite
2. concentrationconcentrated
3. additionThe crude product was diluted with EtOAc
4. washthen washed with water
5. dry with materialThe organic layers was dried with sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated in vacuum
8. customThe crude product was purified by flash chromatography (EtOAc/Heptane eluted at 65% EtOAc)