Hydrochloric Acid → HCID 66763381, compound

HRID 578623Notes

Reaction equation

HRID 578623 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH:14]([NH:16][C:17]2[C:26]3[C:21](=[C:22]([C:27](=[O:29])[NH2:28])[CH:23]=[CH:24][CH:25]=3)[N:20]=[CH:19][N:18]=2)[CH3:15])[CH:9]=1)(C)(C)C.Cl>CO>[NH2:7][C:8]1[CH:9]=[C:10]([CH:14]([NH:16][C:17]2[C:26]3[C:21](=[C:22]([C:27]([NH2:28])=[O:29])[CH:23]=[CH:24][CH:25]=3)[N:20]=[CH:19][N:18]=2)[CH3:15])[CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66763675HCID 66763675, compound

Product 1

HCID 66763381HCID 66763381, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of crude {3-[1-(8-Carbamoyl-quinazolin-4-ylamino)-ethyl]-phenyl}-carbamic acid tert-butyl ester in methanol (20 ml) was added methanolic hydrogen chloride (22.46 ml; 4.00 M; 89.83 mmol; 10.00 eq.). Stirred overnight and the resulting solid was filtered to obtain 2.0 g of the title product in 64% overall yield MS (M+1) 307

Workup

  1. filtrationthe resulting solid was filtered

Sources & evidence

ORD record
ord-dd90fdccdd1c4456bf02e94c13178427
Source dataset
uspto-grants-2015_05
Patent number
US09040560B2

Reaction notes

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