Hydrochloric Acid → HCID 66763549, compound

HRID 578624Notes

Reaction equation

HRID 578624 reaction equation
[NH2:1][C:2]([C:4]1[CH:5]=[C:6]([CH:30]([OH:33])[CH2:31][OH:32])[CH:7]=[C:8]2[C:13]=1[N:12]=[CH:11][N:10]=[C:9]2[NH:14][CH2:15][C:16]1[CH:17]=[C:18]([NH:22]C(=O)OC(C)(C)C)[CH:19]=[CH:20][CH:21]=1)=[O:3].Cl.O1CCOCC1>CO>[NH2:22][C:18]1[CH:17]=[C:16]([CH:21]=[CH:20][CH:19]=1)[CH2:15][NH:14][C:9]1[C:8]2[C:13](=[C:4]([C:2]([NH2:1])=[O:3])[CH:5]=[C:6]([CH:30]([OH:33])[CH2:31][OH:32])[CH:7]=2)[N:12]=[CH:11][N:10]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 68079331HCID 68079331, compound

Product 1

HCID 66763549HCID 66763549, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of tert-butyl [3-({[8-(aminocarbonyl)-6-(1,2-dihydroxyethyl)quinazolin-4-yl]amino}methyl)phenyl]carbamate (25.00 mg; 0.06 mmol; 1.00 eq.) in methanol was added 4.0M hydrogen chloride in dioxane (0.14 ml; 4.00 M; 0.55 mmol; 10.00 eq.). The reaction mixture was stirred at RT for 1 h and evaporated off the solvent to obtain the title compound MS (M+1) 354

Workup

  1. customevaporated off the solvent

Sources & evidence

ORD record
ord-6733c6b30ecc40c199d5e2921d3b5bb2
Source dataset
uspto-grants-2015_05
Patent number
US09040560B2

Reaction notes

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