HCID 66763896, compound → HCID 66763097, compound

HRID 578668Notes

Reaction equation

HRID 578668 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[C:17]([C:19]([NH2:21])=[O:20])[CH:18]=1)[N:15]=[CH:14][N:13]=[C:12]2[NH:22][CH:23]([C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[CH:29]=1)[CH2:24][N:25]([CH3:27])[CH3:26])C1C=CC=CC=1>Br>[Cl:34][C:30]1[CH:29]=[C:28]([CH:23]([NH:22][C:12]2[C:11]3[C:16](=[C:17]([C:19]([NH2:21])=[O:20])[CH:18]=[C:9]([OH:8])[CH:10]=3)[N:15]=[CH:14][N:13]=2)[CH2:24][N:25]([CH3:27])[CH3:26])[CH:33]=[CH:32][CH:31]=1

Participants

3

Reactant 1

HCID 66763896HCID 66763896, compound

Product 1

HCID 66763097HCID 66763097, compoundYield 13%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

In a 20 mL scintillation vial 6-Benzyloxy-4-[1-(3-chloro-phenyl)-2-dimethylamino-ethylamino]-quinazoline-8-carboxylic acid amide was taken in 5 ml of aqueous HBr solution and stirred at room temperature for 2 h. Reaction was concentrated and dissolved in methanol and the crude was purified on preparative HPLC to give the product, (7.0 mg, 13% yield). LCMS (ESI) 386 (M+H)

Workup

  1. customReaction
  2. concentrationwas concentrated
  3. dissolutiondissolved in methanol
  4. customthe crude was purified on preparative HPLC
  5. customto give the product, (7.0 mg, 13% yield)

Sources & evidence

ORD record
ord-90598d013b2a4bb98ea4bee3683b537b
Source dataset
uspto-grants-2015_05
Patent number
US09040560B2

Reaction notes

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