Hydrochloric Acid → HCID 77014393, compound

HRID 578681Notes

Reaction equation

HRID 578681 reaction equation
C(OC(=O)[NH:7][C:8]1[S:9][CH:10]=[C:11]([C:13](=[O:36])[NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][NH:22][C:23]3[C:32]4[C:27](=[C:28]([C:33](=[O:35])[NH2:34])[CH:29]=[CH:30][CH:31]=4)[N:26]=[CH:25][N:24]=3)[CH:16]=2)[N:12]=1)(C)(C)C.Cl>O1CCOCC1>[NH2:7][C:8]1[S:9][CH:10]=[C:11]([C:13]([NH:14][C:15]2[CH:16]=[C:17]([CH:18]=[CH:19][CH:20]=2)[CH2:21][NH:22][C:23]2[C:32]3[C:27](=[C:28]([C:33]([NH2:34])=[O:35])[CH:29]=[CH:30][CH:31]=3)[N:26]=[CH:25][N:24]=2)=[O:36])[N:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86662388HCID 86662388, compound

Product 1

HCID 77014393HCID 77014393, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

64 mg (0.12 mmol) of (4-{3-[(8-Carbamoyl-quinazolin-4-ylamino)-methyl]-phenylcarbamoyl}-thiazol-2-yl)-carbamic acid tert-butyl ester were dissolved in 1.0 ml dioxane and 620 μl 4 N HCl in dioxane were added. The mixture was stirred overnight and evaporated to dryness.

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-4ee592f0f1a2413ab0630971cc002c96
Source dataset
uspto-grants-2015_05
Patent number
US09040560B2

Reaction notes

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