Hydrochloric Acid → HCID 66763954, compound

HRID 578687Notes

Reaction equation

HRID 578687 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]2[N:14]=[CH:15][C:16]([C:17](=[O:40])[NH:18][C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([CH2:25][NH:26][C:27]4[C:36]5[C:31](=[C:32]([C:37](=[O:39])[NH2:38])[CH:33]=[CH:34][CH:35]=5)[N:30]=[CH:29][N:28]=4)[CH:20]=3)=[C:10]2[CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[N:14]1[N:11]2[CH2:12][CH2:13][NH:8][CH2:9][C:10]2=[C:16]([C:17]([NH:18][C:19]2[CH:20]=[C:21]([CH:22]=[CH:23][CH:24]=2)[CH2:25][NH:26][C:27]2[C:36]3[C:31](=[C:32]([C:37]([NH2:38])=[O:39])[CH:33]=[CH:34][CH:35]=3)[N:30]=[CH:29][N:28]=2)=[O:40])[CH:15]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66762706HCID 66762706, compound

Product 1

HCID 66763954HCID 66763954, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

37 mg (0.56 mmol) 3-{3-[(8-Carbamoyl-quinazolin-4-ylamino)-methyl]-phenylcarbamoyl}-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxylic acid tert-butyl ester were dissolved in 1.5 ml dioxane and 280 μl 4 N HCl in dioxane were added. The mixture was stirred overnight and evaporated to dryness. 30 mg, off-white solid. Product is the hydrochloride salt.

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-a45a34c8686644f59b0c1acb93eaefc4
Source dataset
uspto-grants-2015_05
Patent number
US09040560B2

Reaction notes

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