Hydrochloric Acid → HCID 66762254, compound

HRID 578694Notes

Reaction equation

HRID 578694 reaction equation
[NH2:1][C:2]([C:4]1[CH:5]=[C:6]([CH:30]([OH:33])[CH2:31][OH:32])[CH:7]=[C:8]2[C:13]=1[N:12]=[CH:11][N:10]=[C:9]2[NH:14][CH2:15][C:16]1[CH:17]=[C:18]([NH:22][C:23](=[O:29])OC(C)(C)C)[CH:19]=[CH:20][CH:21]=1)=[O:3].Cl.O1[CH2:40][CH2:39][O:38][CH2:37]C1>CO>[OH:33][CH:30]([C:6]1[CH:7]=[C:8]2[C:13](=[C:4]([C:2]([NH2:1])=[O:3])[CH:5]=1)[N:12]=[CH:11][N:10]=[C:9]2[NH:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([NH:22][C:23](=[O:29])[C:4]2[CH:2]=[CH:40][C:39]([O:38][CH3:37])=[CH:8][CH:13]=2)[CH:17]=1)[CH2:31][OH:32]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 68079331HCID 68079331, compound

Product 1

HCID 66762254HCID 66762254, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of tert-butyl [3-({[8-(aminocarbonyl)-6-(1,2-dihydroxyethyl)quinazolin-4-yl]amino}methyl)phenyl]carbamate (25.00 mg; 0.06 mmol; 1.00 eq.) in methanol was added 4.0M hydrogen chloride in dioxane (0.14 ml; 4.00 M; 0.55 mmol; 10.00 eq.). The reaction mixture was stirred at RT for 1 h and evaporated off the solvent to obtain the title compound MS (M+1) 354.

Workup

  1. customevaporated off the solvent

Sources & evidence

ORD record
ord-d8b7148b7f38433cbfb81a39ecbfe89b
Source dataset
uspto-grants-2015_05
Patent number
US09040560B2

Reaction notes

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